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2nd International
Technical Forum Inspiring Powder Technology Date:
November9（Thu.）,2006 Session1: 13:00-14:00, Venue: Makuhari
Messe International Conference Hall Room 201 |
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A (drug
design) |
B (nanotechnology) |
C (crystallization) |
D (others) |
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A01 |
Design of Rapid disintegrating tablets formulated silica
composite particle with drying method |
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Yohei Hoashi1), Ayako Ban2), Yuichi Tozuka2),Hirofumi
Takeuchi2), Toshiya Kai1), Makoto Sato2) |
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1）NIPROCORPORATION, 2）GifuPharmaceutical
University |
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Usual direct conpaction method is desired
t obe applied for manufhcturing the rapid disintegrating tablets(RDTs）. Sugar alcohol can be a candidate for the diluents of
RDTs. However, these powders are poor compactibility. Previously, we reported
that compactibility of these powders was much improved by formulating the
composite particles prepared with the porous Silica and sugar alcohols by
using spray-drying method, into the tablet formulation. In the present study,
the silica composite particles were prepared by drying methods such as
ball-mill or mechanofusion. The composite particles were also effbctive in
improving compactibility of the sugar alcohol particles. |
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A02 |
Design of submicron sized W/0/W emulsion for pharmaceutical
application |
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Fujita Naomi1),
Tozuka Yuichi1), Takeuchi Hirohumi2), Nagahama Tohru2),
AketoTakao1) |
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1）GifuPharmaceuticalUniversity, 2）TaishoPharmaceuticalCo.Ltd, |
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The submicron sized and stable W/0/W
emulsion was prepared with a novel membrane apparatus. The properties of
model drug loaded emulsions were evaluated in the points of pharmaceutical application.
We also checked the feasibility of conversion of the emulsion into the
redispersible dry emulsion by using freeze dry method. In addition, we
observed the behavior of the W/0/W emulsion after oral administration in
rats. |
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A03 |
Evaluation of adhesive property of pharmaceuticals by
surface free energy analysis |
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Yonemochi
Etsuo |
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Toho
Univeristy |
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Adhesive property of pharmaceuticals to metal
alloy was evaluated. Tool steel(SKS), chromium-nickel alloy(CAN), and
stainless alloy(SUS) were used as model alloy, and citric acid hydrate(CAH)
was used as model drug. Surface free energy of CAH was similar to that of
SKS, which was commolnly used for tabletting machine .This result suggested
that the surface free energy measurement would be useful to estimate the
adhesive propertiy of pharmaceuticals |
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A04 |
Evaluation of dispersive state of drug in the tablet using NIR
chemical imaging and their quantitative precision |
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Asuka Ozawa1),
Yasuo Yoshihashi1), Etsuo Yonemochi1), Tatsuo Koide2), |
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1) |
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In this study the content uniformity of
each tablet was evaluated by conventional method and Near-infrared
spectroscopy (NIRS). Dispersive state of drug in the tablet was also
evaluated using NIR chemical imaging. In the tablet containing the drug
1%-15%, acetaminophen particles were cohered. On the other hand, anhydrous
caffeine was dispersed as a small particle on the surface of a tablet.
Therefore NIR chemical imaging is useful tool to consider a dispersive state
of tablets of different ingredient, content and particle diameter. |
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A05 |
Application of mechano-fusion method for improvement of
inhalation characteristic of drug. |
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Satoshi
Machida |
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Toho
Univeristy |
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Change in the physical properties of drug
for inhalation drug treated by mechano-fusion method was examined. Lactose
and triamcinolone acetonide were used for model carrier and drug,
respectively. Magnesium stearate(Mg-St) and sucrose stearate were used for
the additive. Surface roughness and surface free energy of the career were
changed by mechano-fusion, and these parameters were related to the
inhalation characteristics of drug. Mechanofusion with Mg-St or sucrose
stearate could be an effective method to improve inhalation property of a DPI
drug formulation. |
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A06 |
Study on functions of super disintegrant "Kollidon CL
grades" and the application to pharmaceutical solid dosage form |
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Mitsunori
Tanabe |
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BASF Japan
Ltd. |
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The propose of this study was to product spherical
micron-size ceramic powder using by induction thermal plasma process. The
characterization of treated particles was investigated by SEM, BET, XRD,
particle size mesurment, sphericity mesurement and so on. The flowability was
improved and the bulk packing density of prepared spherical particles was
increased as compared with raw material. We will report the spheroidization
method of ZrO2, Al2O3 and BTO powder. |
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A07 |
Use of Spouted Bed Binderless Granulation to Design PLGA Nanocomposite Particles for Dry Powder Inhalation |
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K.Hara,
H.Tsujimoto, Y.Tsukada, S.Hatano, Y.Kawashima |
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Hosokawa
Particle Technology Research Institute |
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Recently, the drug loaded PLGA naospheres
possessing high pharmacological effects have been hoped to be great pulmonary
delivery carrier particles applied to the dry powder inhalation (DPI) for
systemic or locality threatment. However, there are several problems in terms
of practical use on poor handling and re-dispersion due to strong cohesive
properties of PLGA nanosperes. In this study, we proposed new granulation
technique using a spouted bed type binderless granulator and a jet mill to
make the applicable PLGA nano-composite partcles as DPI. In the method, the
PLGA nano-composite granules having a spherical shape with soft granule
strength can be binderless granulated in the spouted bed using raw materials
which are precise mixtures consisting of pre-freeze dried PLGA nanospheres
and lactose powder processed by jet mill. The nano-composite granules showed
good handling properties with high RF (respirable fraction estimated by
cascade impactor) values in vitro tests. The new granulation method proposed
here was suggested to be a useful preparation technique of PLGA
nano-composite granules for DPI application. |
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A08 |
The developments of NFκB Decoy
Oligodeoxynucleotides loaded PLGA nanosphere and the applications for atopic
dermatitis |
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Y.Tsukada, H.Tsujimoto,
K.Hara, M.Sakaguchi, M.Aoki, R.Morishita, Y.Kawashima |
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HOSOKAWA
POWDER TECHNOLOGY RESEARCH INSTITUTE |
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Although NFkB decoy oligodeoxynucleotides
(NDON) has high pharmacologic effect on atopic dermatitis (AD), both of the skin
permeability and the transfection efficiency of NDON are strongly demanded to
expand an application parts having high barrier function, excepting a face as
a conventional application part whose barrier function is low. In this study, we prepared several
type of NDON loaded |
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A09 |
Grinding-induced solubilization and nanoparticle formation
of poorly-soluble drugs: Clarithromycin and ascorbic acid 2-glucoside binary
system |
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Yutaka Inoue1),
Yuichi Tozuka2), Kunikazu Moribe1), Takuya Kumamoto1), |
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1) |
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Clarithromycin (CMA) was co-ground with ascorbic
acid 2-glucoside (AA-2G) to improve the solubility characteristics. The
complete solubilizing effect of AA-2G was observed for the ground mixture
with 1:1 molar ratio. The 1H- and 13C-NMR spectra revealed
that the solubilization effect was attributable to the interaction between |
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A10 |
【New Product】Super High Compactible MCC Ceolus® KG−1000 |
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Kazuhiro
Obae |
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ASAHI KASEI
CHEMICALS CORPORATION |
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A11 |
galenIQTM , A new definition of a
multifunctional excipient |
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Teraoka
Makoto |
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HIGUCHI Inc. |
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galenIQTM is developed and
produced by Palatint GmbH in |
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A12 |
Preparation of nanoparticles and application to fine
particulate coating by laser ablation method |
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Sanshiro
Nagare |
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Nara
Machinery Co., Ltd. |
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We introduce nanoparticles preparation
technology using laser ablation method with high energy pulsed laser at
reduced pressure. In situ coating
of these nanoparticles on substrates as well as on the surface of particulate
systems are also introduced with some applications. Laser ablation in the
liquid phase for direct preparation of nano-suspensions is presented as well. |
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A13 |
Proparation of Sustained Release Fine Particles by the Dry
Coating Method with a Mechanochemical Disporsing Device |
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Hiroshi
Yuasa |
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A14 |
Powder surface area, pore size distribution and porosity by
gas adsorption |
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Kouji
Miyazawa |
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Yuasa-Ionics
Co.., Ltd. |
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In particle design, the specific surface
area, pore size distribution and porosity of powder and a granule serve as a
intarest parameter. The intra structure of particles can be grasped in
analyzing an absorption phenomenon by using an inert gas molecule as a probe.
Moreover, if the molecule of water is used, hydrophilic and hydrophobic
surface can be evaluated and ammonia gas and carbon dioxide will be used, the
chemical property on the surface of materials, such as acid and basic is also
measurable. |
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A15 |
R&D Spray dryer for fine particle |
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Masashi
Fujii, Yukie Takeshita |
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Ohkawara
Kakohki Co., Ltd. |
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A16 |
Percolation Theory and the Role of Maize Starch as a
Disintegrant for a Low Water Soluble Drug |
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Go Kimura1,2),
Maxim Puchkov1), Gabriele Betz1), Hans Leuenberger1,3) |
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1) |
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The critical concentration of maize
starch according to the percolation theory for a ternary system with respect to
a minimum disintegration time was investigated. This works demonstrated that
the application of percolation theory is not limited to the binary systems
and how it can be used to analyse the behaviour of binary and ternary systems
for caffeine and mefenamic acid formulations containing a starch-based
disintegrant. The percolation threshold pc can be described by the volumetric
ratio of the disintegrant to the drug substance being close to pc=0.2 (v/v)
in case that both components have similar average particle sizes. Moreover
the behaviour of the disintegration time in the neighbourhood of the
percolation threshold can be mathematically modelled with the basic equation
of the percolation theory yielding a critical exponent q=0.3 |
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A17 |
New turret exchangeable application 「AQUARIUS GLOBAL」 |
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Katsuhito
Fujisaki |
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KIKUSUI
SEISAKUSYO LTD. |
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B (nanotechnology) |
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B01 |
Ceramic Powder Spheroidization by Induction Thermal Plasma |
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Yubuta
Kazuhiro |
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Nisshin
Seifun Group Inc. |
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The propose of this study was to product
spherical micron-size ceramic powder using by induction thermal plasma
process. The characterization of treated particles was investigated by SEM,
BET, XRD, particle size mesurment, sphericity mesurement and so on. The
flowability was improved and the bulk packing density of prepared spherical
particles was increased as compared with raw material. We will report the
spheroidization method of ZrO2, Al2O3 and BTO powder. |
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B02 |
Gas-phase dispersion of liquid-phase nanoparticles to
measurement of particle size distribution |
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Wuled
Lenggoro |
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A nanoelectrospray-furnace-scanning mobility
size spectrometer (SMPS) system was developed which is capable a rapidly and
accurately measuring the size distributions of colloidal nanoparticles. Many
colloidal suspensions require the use of involatile surfactants to stabilize
the suspensions. High temperature heating in the furnace was also used to
evaporate the nanoparticles themselves, which shifted the nanoparticle size
spectra to smaller sizes. By comparing the size spectra shift of particles of
unknown chemical composition to size spectra shift of nanoparticles of a
known size and chemical composition, the electrospray-furnace-SMPS system can
be used for nanoparticle chemical identification. |
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B03 |
Micrometer-Scale Patterning of SnO2 Nano Powders by the
Micromolding in Capillaries (MIMIC) Method |
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Imasu Junko,
Sakka Yoshio, Fudouzi Hiroshi |
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National
Institute for Materials Science |
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We have been studying micrometer-scale patterning
of ceramic suspensions by the MIMIC method, which is one of the
soft-lithographies and uses capillary action to fill mold channels. In the
case of applying a few vol% ethanol suspensions of ceramic nano powders to
MIMIC, dense and thick patterns are generated over a wide area. We report on
the Tin Oxide striped patterns with about 20 µm in width
and millimeter-scale in length fabricated by this process. |
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B04 |
Synthesis of hollow calcium carbonate particles in a
non-equilibrium processing |
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Watanabe
Hideo |
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Nagoya
Institute of Technology |
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Hollow calcium carbonate particles are
synthesized in non-equilibrium of carbonate ions formed by bubbling CO2 gas
into CaCl2 solution. In this work,
the effect of the initial pH of the CaCl2 solution on the morphology of the
hollow particles synthesized is investigated, and aggregation processes of
CaCO3 particles is discussed by means of an on-line monitoring the
transmitted light strength of the CaC12 solution with continuous bubbling
CO2. |
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B05 |
An Introduction of Bubble Template Method For Synthesis of
Hollow Particles |
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Han Yong
Sheng |
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Nagoya
Institute of Technology |
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A novel method to synthesize hollow particles
has been proposed in our group with the nomination of bubble template method.
Hollow particles are formed by assembling primary particles on the surface of
bubbles. In this method, bubbles are not only reactants, but also the
template for the formation of hollow particles. Hollow particles of CaCO3,
silica gel and ZnO have been successfully prepared by this method. It was
proved that this method is an efficient process for synthesis of hollow
particles with the characteristics of low cost and high production. |
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B06 |
Arrangement of particles using capillary electro osmotic
flow. |
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Endo,
Takeshi |
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Nagoya
Institute of Technology |
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Electro-osmotic flow, which occurs simultaneously
in capillary electrophoresis, is utilized to transport small particles. An
arrangement of PMMA particles originally in anode cell has been attempted
with respect to a variety of solutions in cathode cell. The particle issued
from the tip of a capillary is moved by electro-osmotic flow and is
eventually deposited by its gravity onto a plate set in the cathode cell. A designated pattern of the deposited particles can be
formed by controlling the position of the plate during moving of the particle. |
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B07 |
- |
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Nukanobu
Atsushi |
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NIKKISO
CO.,LTD. |
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B08 |
Evaluation of alumina slurry using capillary
electrophoresis. |
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Yamakawa,
Tomohiro |
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Nagoya
Institute of Technology |
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Reliability of ceramics is intimately
linked with the dispersion characteristic of slurry. It is important that
evaluation of slurry is very important since slurry of characterization
changes with temperature variation and so on. This study is to attempt a
slurry evaluation using capillary electrophoresis. By this our new technique,
it is confirmed that precipitation of slurry can determine quantity through
the capillary electrophoresis. |
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B09 |
Preparation of Zinc Sulfide Nanoparticles by Colloidal Method
and Their Engineering Application |
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Yasuyuki
Arao, Yasushige Mori |
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Zinc sulfide nanoparticles (ZnS NPs) were
prepared by colloidal method.
Smectite clay and thioglycerol can be used as agents to prevent
agglomeration. Nanocomposite
consisted of ZnS NPs and smectite has high photocatalytic activity for the
production of hydrogen gas from water.
ZnS NPs prepared in the
thioglycerol solution can not only prevent agglomeration, but also
assist to dope metal ions. ZnS
NPs to dope metal ion could be expected new wave length of photoluminescence. |
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B10 |
Raman Spectroscopy and the PAT Initiative |
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Keijiro
Terashita1), Tsuyoshi
Furukawa2), Hiroshi
Hisada2), Shukichi
Ochiai2) |
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1) Osaka
Lifie Science Labo 2) S.T. Japan
Inc. |
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B11 |
Properties Control of Cosmetic Fine Spherical Silica
Particles by Surface Modification |
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Tamonoki Maki,
Tsukada Mayumi, Kani Toshiyuki, Suzuki Takahiro and Kamiya Hidehiro |
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This study focused on the surface
modification of cosmetic powders for the powder behavior control. The surface
interaction between fine spherical nanoporous and fused silica particles with
surface modification by silane coupling agent and mica was characterized by
colloid probe AFM method. |
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B12 |
Emission Behavior of Condensible Suspended Particulate Matter from Stationary
Combustion Sources |
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Nishikawa Nakaha,
Liu Yuyu, Tsukada Mayumi,
Kamiya Hidehiro |
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Suspended particulate matter (SPM) is one of the air pollutants,
which cause respiratory diseases. Among the SPMs
emitted from stationary sources, such as waste incinerators, condensible SPM is important for its complexity in
generation mechanism. In order to evaluate the emission behavior of condensible SPM, model flue gas containing Cd or Pb compounds was streamed
through a bag filter, and cooled by air dilution systems. The particle size
of liberated condensible SPM was primarily less
than 10 nm in diameter, and emission concentration was decreased by fly ash
deposition on a bag filter. |
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C01 |
A New Crystallization Method Using Liquid/Liquid Interface
for Fabrication of Asymmetric Particles |
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Kadota
Kazunori |
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We proposed a new process of
crystallization for making asymmetric particles. Liquid/liquid interface,
which is constructed from two solvents with a little solubility each other,
is used in the process. The crystallization can be performed without heating and
mixing and controlled by contact time of two liquids and concentration of the
solute. It means that the process is very simple and easy to controlling the
particulate size distribution. The appropriate choices of the solvents lead
to a particulate design in this process. |
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C02 |
Application of Microwave Irradiation to Crystallization of
Carbonate Nano-Particles |
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Masakazu
Matsumoto, Souichiro Hirose, Tomohiro Fukunaga, Kaoru Onoe |
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Chiba
Institute of Technology |
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Carbonate has been utilized in a wide
variety of industrial fields such as paper, pigments, medicine, and
food. Such industrial
applications require well-defined carbonate, which consist of particles with
a fine size, narrow size distribution, uniform shape and crystal structure
(polymorphs). In this study,
microwave irradiation（2.45GHz）that can
activate liquid phase has been applied to crystallization of carbonate
nano-particles. Microwave was
irradiated to the supersaturated solution of carbonate, and microwave power
was varied as an operating parameter.
Consequently, it might be possible to obtain lithium carbonate
particles that have an average size of 400 nm when microwave power was
adjusted at 400W. |
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C03 |
Growth Rate Changes of Gypsum |
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Shigehiro
Kagaya 、Akihiro Shiroishi |
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Engineering
Department, |
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It is well known that addtion of
additives or co existant impurities in the solution usually prevents more or less
the growth rate of the crystal
But it was found in our experiment that some surfactants additon in to
the solution resulted in the inclease of growth rate of the crystal on the
case reactive crystallization using calcium chloride soluiton and surfuric
acid solution carried out to produce gypsum crystal. |
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C04 |
Fuzzy Logic Control of a Batch Crystallizer |
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Sohrab
Rohani |
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The |
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A fuzzy logic control methodology is developed
for the control of a seeded semi-batch crystallizer. Crystallization of
paracetamol (PA) in isopropanol-water mixtures was used as the model system.
The concentration and cord length counts were measured using an in-situ
ATR-FTIR and an in-situ FBRM® probe, respectively. Three open loop
feeding policies; Concave (CCFP, similar to natural cooling); Linear (LFP);
and Convex (CVFP, near controlled cooling); were employed to investigate the
process dynamic behavior in order to construct the fuzzy controller structure
for the control of supersaturation within a predefined zone close to the
solubility curve. It is found that the fuzzy controller can ensure tracking
of the concentration within the zone leading to substantial improvement of
the end product size distribution. Selecting the initial PA concentration
above the upper limit of the concentration results in longer process times.
The open-loop results show that the feeding policy (addition of water) does
not prevent the nucleation and agglomeration, however, both phenomena can be
minimized by the LFP. |
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C05 |
Increase in crystal growth rate for production of sodium
chloride |
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Koji Masaoka |
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The |
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The effects of the number of suspended fine
crystals in a mother liquid on the crystal growth rate of sodium chloride was
studied using a fluidized bed type crystallizer, as a fundamental study for
the obtaining a high crystal growth rate. In addition, influences of high
crystal growth rate on the amount of liquid inclusion were studied using
fluidized bed type and mixing type crystallizers. Within the confines of the examination
conditions, crystal growth rate increased with the number of suspended fine
crystals. The increase in the
growth rate had little influence on the amount of liquid inclusion in the
crystal products |
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C06 |
IN SITU OBSERVATION OF NUCLEATION AND |
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Tatsuya Okubo |
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The |
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The formation and the consumption of
nanosized precursors during the synthesis of nanosized zeolite Linde type A
(LTA) are studied by in situ small angle X-ray scattering (SAXS). The SAXS data indicate that two sized
particles (ca. 0.5 nm and ca. 4.5 nm) are formed prior to the
onset of the formation of LTA crystals, and the 4.5 nm sized precursor
particles significantly affect the crystallization process. Moreover, the effects of Na+
and TMA+ on the crystallization are studied. |
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D01 |
Simulation tool for process engineers and researchers |
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Gad Amir |
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VixiMix |
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VisiMix software is a simulation tool for
process engineers and researchers. The VisiMix programs are based on the combination
of the most modern physical and mathematical models with accumulated practical experience
in mixing technology and process engineering. They provide data on average
and local parameters of
hydrodynamics, turbulence, mass- and heat transfer for practically all
process applications, including suspension, drop breaking, dissolution,
crystallization, gas consumption, etc.
The programs are widely used for
development, improvement and
optimization of mixing, heat and mass transfer and reaction processes
in existing and new mixing equipment. Among the customers - Dow Chemicals, Pfizer,
GlaxoSmithKline, 3M, Mitsubishi Chemicals, Nippon Chemical, Xerox, Unilever,
Eli Lilly, Schering Plough, Hercules,
General Electric, Chevrontexaco and other leading chemical producers. |
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D02 |
Desktop crystallization |
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Hamp Turner |
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Turner Technology |
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The ability to quickly perform accurate estimations of
processes is invaluable to designers and operators of crystallization unit
operations. Fundamental calculations include determination of thermodynamic
equilibrium, estimation of supersaturation levels,
and material and energy balances. CalcAQ provides
just such a tool as a user-friendly add-in module to Microsoft's ubiquitous
Excel spreadsheet interface. Using design criteria or online measurements,
calculation of fundamental parameters can be combined with available
crystallization models for improved estimation results. This paper describes
advances in this area. |